Georgiana Cîrstea, Aurelian Denis Negrea, Sorin Georgian Moga, Florentina Popa, Ecaterina Magdalena Modan, Ionela Rusea, Alin Din, Denisa Ștefania Vîlcoci
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bioactivity, bioinformatics approach, Burgund grape pomace, resveratrol
This study explores a sustainable strategy for recovering and assessing the bioactivity of resveratrol from Burgund grape pomace. Wet and dried pomace were milled and subjected to microwave-assisted extraction (MAE) with 99.9% ethanol (1:10 w/v, 20 min). Wet pomace yielded a slightly higher total polyphenol content (6.25 mg GAE/g) than dried samples (6.13 mg GAE/g). UHPLC analysis confirmed resveratrol levels of 0.047–0.055 µg/mL in wet pomace, exceeding those in dried samples. Antioxidant activity (DPPH assay) correlated strongly with polyphenol content. In silico profiling indicated compliance with Lipinski’s and Veber’s rules, high intestinal absorption (~91%), moderate permeability, CYP3A4-mediated metabolism, and a favorable safety profile. These findings demonstrate the efficiency of MAE and underline the therapeutic potential of resveratrol, supporting grape pomace as a reproducible, ethical, and eco-responsible resource.
Cite this paper: Cîrstea, G., Negrea, A.D., Moga, S.G., Popa, F., Modan, E.M., Rusea, I., Din, A., Vîlcoci, D.Ș. (2025). FROM WASTE TO HEALTH: AN INTEGRATIVE BIOINFORMATICS APPROACH TO THE THERAPEUTIC POTENTIAL OF BURGUND GRAPE POMACE EXTRACTS OBTAINED BY MICROWAVE-ASSISTED EXTRACTION. Current Trends in Natural Sciences, 14(27), 68-77. https://doi.org/10.47068/ctns.2025.v14i27.008
